1. Figure 10.13 Rb and other proteins that negatively regulate the cell cycle are sometimes called tumor suppressors. Why do you think the name tumor suppressor might be appropriate for these proteins?
2. Figure 10.14 Human papillomavirus can cause cervical cancer. The virus encodes E6, a protein that binds p53. Based on this fact and what you know about p53, what effect do you think E6 binding has on p53 activity?
- E6 activates p53
- E6 inactivates p53
- E6 mutates p53
- E6 binding marks p53 for degradation